Natural Human Thyroglobulin protein (ab96518)

製品の概要

製品の詳細

  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • アクセッション番号P01266
    • 生物種Human
    • 分子量303 kDa
    • 領域20 to 2768

特性

Our Abpromise guarantee covers the use of ab96518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Radial Immunodiffusion

    SDS-PAGE

    Western blot

  • 精製度>= 96 % SDS-PAGE.
    Nominally greater than 96% of the protein is Thyroglobulin.
  • 製品の状態Lyophilised
  • 備考Starting material pool is tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C.

    Constituent: 0.2% Ammonium bicarbonate
    Note: May contain traces of buffer salts.

  • 再構成Use of phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended.

関連情報

  • 別名
    • AITD 3
    • AITD3
    • hTG
    • TDH3
    • Tg
    • TGN
    • THYG_HUMAN
    • Thyroglobulin
    see all
  • 機能Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
  • 組織特異性Thyroid gland specific.
  • 関連疾患Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
    Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
  • 配列類似性Belongs to the type-B carboxylesterase/lipase family.
    Contains 11 thyroglobulin type-1 domains.
  • 翻訳後修飾Sulfated tyrosines are desulfated during iodination.
  • 細胞内局在Secreted.
  • Information by UniProt

Natural Human Thyroglobulin protein 画像

  • Anti-Thyroglobulin antibody (ab48628) at 5 µg/ml + Natural Human Thyroglobulin protein (ab96518) at 0.01 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 10 seconds

Natural Human Thyroglobulin protein (ab96518) 使用論文

ab96518 has not yet been referenced specifically in any publications.

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