Natural Human Thyroglobulin protein (ab96518)

製品の概要

製品の詳細

  • 由来
    Native
  • 由来
    Native
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      303 kDa
    • 領域
      20 to 2768

特性

Our Abpromise guarantee covers the use of ab96518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Radial Immunodiffusion

    SDS-PAGE

    Western blot

  • 精製度
    >= 96 % SDS-PAGE.
    Nominally greater than 96% of the protein is Thyroglobulin.
  • 製品の状態
    Lyophilised
  • 備考
    Starting material pool is tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C.

    Constituent: 0.2% Ammonium bicarbonate
    Note: May contain traces of buffer salts.

  • 再構成
    Use of phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended.

関連情報

  • 別名
    • AITD 3
    • AITD3
    • hTG
    • TDH3
    • Tg
    • TGN
    • THYG_HUMAN
    • Thyroglobulin
    see all
  • 機能
    Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
  • 組織特異性
    Thyroid gland specific.
  • 関連疾患
    Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
    Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
  • 配列類似性
    Belongs to the type-B carboxylesterase/lipase family.
    Contains 11 thyroglobulin type-1 domains.
  • 翻訳後修飾
    Sulfated tyrosines are desulfated during iodination.
  • 細胞内局在
    Secreted.
  • Information by UniProt

画像

  • Anti-Thyroglobulin antibody (ab48628) at 5 µg/ml + Natural Human Thyroglobulin protein (ab96518) at 0.01 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 10 seconds

参考文献

ab96518 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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