Natural human Plasma Kallikrein 1B protein (ab77870)

製品の概要

製品の詳細

  • 由来
    Native
  • 由来
    Native
  • アミノ酸配列
    • 生物種
      Human

特性

Our Abpromise guarantee covers the use of ab77870 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    Specific activity: >=15 units per mg. One unit is defined as the amount of enzyme that will hydrolyze 1µmole of D-Pro-Phe-Arg-pNA (Chromogenix S-2303) per minute at 25°C, pH 7.8.
  • アプリケーション

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20mM Tris HCl, 100mM Sodium chloride, pH 7.8

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成
    Reconstitute with 104ul distilled water to get a 0.481 mg/ml solution. (0.3mg/ml (prior to lyophilization).)

関連情報

  • 別名
    • Fletcher factor
    • kallikrein B plasma
    • Kallikrein B plasma (Fletcher factor) 1
    • Kallikrein B, plasma 1
    • Kallikrein B1
    • Kininogenin
    • KLK3
    • KLKB1
    • KLKB1_HUMAN
    • PKK
    • PKKD
    • Plasma kallikrein
    • Plasma kallikrein B1
    • Plasma kallikrein light chain
    • Plasma prekallikrein
    • PPK
    • Prekallikrein
    see all
  • 機能
    The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
  • 関連疾患
    Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
  • 配列類似性
    Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
    Contains 4 apple domains.
    Contains 1 peptidase S1 domain.
  • 細胞内局在
    Secreted.
  • Information by UniProt

参考文献

ab77870 has not yet been referenced specifically in any publications.

レビューと Q&A

The source of the Plasma Kallikrein 1B protein ab77870 informed me that the purification method is proprietary information and cannot be provided.

Sorry we can't be more helpful on this occasion.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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