Natural human Myeloperoxidase protein (ab91116)

製品の概要

製品の詳細

  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab91116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Activity: 180-220 units per mg protein after lyophilization. One unit of activity is defined as the amount of enzyme that will decompose one micromole of hydrogen peroxide per minute at 25°C, pH 6.1. Reaction mixture contains 33 mM sodium phosphate, pH 6.1, 30 mM guaiacol, and 0.0012% (0.35 mM) hydrogen peroxide.
  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Lyophilised
  • 備考Protein Determination: Extinction Coefficient (E) 0.1% at 280nm, 1cm pathway = 1.45. Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20ºC.

    Preservative: None
    Constituents: 50mM Sodium acetate, 100mM Sodium chloride, pH 6.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • 84 kDa myeloperoxidase
    • 89 kDa myeloperoxidase
    • EC 1.11.1.7
    • EC1.11.2.2
    • fj80f04
    • MPO
    • mpx
    • myeloid-specific peroxidase
    • Myeloperoxidase
    • Myeloperoxidase heavy chain
    • Myeloperoxidase light chain
    • PERM_HUMAN
    • wu:fj80f04
    see all
  • 機能Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
  • 関連疾患Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
  • 配列類似性Belongs to the peroxidase family. XPO subfamily.
  • 細胞内局在Lysosome.
  • Information by UniProt

Natural human Myeloperoxidase protein 画像

  • SDS-PAGE: 4-12% Bis-Tris gel
    Lane 1. 5 µg Myeloperoxidase (reduced/heated)
    Lane 2. 10 µg Myeloperoxidase (reduced/heated)
    Lane 3. 20 µg Myeloperoxidase (reduced/heated)
    Lane 4. Molecular weight markers

Natural human Myeloperoxidase protein (ab91116) 使用論文

ab91116 has not yet been referenced specifically in any publications.

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