Natural Human IgM protein (ab90348)

関連情報

• 別名
  • AGM1
  • Constant region of heavy chain of IgM
  • DKFZp686I15196

  • DKFZp686I15212
  • FLJ00385
  • Hepatitis B virus receptor binding protein
  • Ig mu chain C region
  • IGHM
  • IgM heavy chain constant region
  • Immunoglobulin heavy constant mu
  • Immunoglobulin mu chain
  • Imunoglobulin heavy chain
  • Imunoglobulin heavy chain constant region mu
  • Imunoglobulin heavy chain mu constant region
  • MGC104996
  • MGC52291
  • MU
  • VH

  see all
• 関連性
  IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.
• 細胞内局在
  Isoform 1: Secreted. During differentiation, B lymphocytes switch from expression of membrane bound IgM to secretion of IgM. Isoform 2: Cell membrane; Single pass type I membrane protein.