Natural Human Factor XIIIa protein (ab62412)

製品の概要

  • 製品名Natural Human Factor XIIIa protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab62412 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態Liquid
  • 備考

    Enzymatic FXIIIa is composed of A2'B2. Ab62412 is the active, enzymatic tetrameric form (A2'B2) in absence of calcium ions. In contrast to the inactive tetrameric FXIII (A2B2), ab62412 has been activated by thrombin.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 0.5mM EDTA

関連情報

  • 別名
    • bA525O21.1 (coagulation factor XIII, A1 polypeptide)
    • Coagulation factor XIII A chain
    • Coagulation factor XIII A1 polypeptide
    • Coagulation factor XIII A1 subunit
    • Coagulation factor XIII, A polypeptide
    • Coagulation factor XIIIa
    • F13A
    • F13A_HUMAN
    • F13a1
    • Factor XIIIA
    • Fibrin stabilizing factor, A subunit
    • Fibrinoligase
    • FSF, A subunit
    • Protein glutamine gamma glutamyltransferase A chain
    • Protein-glutamine gamma-glutamyltransferase A chain
    • TGase
    • Transglutaminase A chain
    • Transglutaminase. plasma
    see all
  • 機能Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
  • 関連疾患Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
  • 配列類似性Belongs to the transglutaminase superfamily. Transglutaminase family.
  • 翻訳後修飾The activation peptide is released by thrombin.
  • 細胞内局在Cytoplasm. Secreted. Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
  • Information by UniProt

Natural Human Factor XIIIa protein 画像

  • Lane 1 : Non-reduced Factor XIIIa protein (ab62412) at 1 µg
    Lane 2 : Molecular weight standard
    Lane 3 : Reduced Factor XIIIa protein (ab62412) at 1 µg
    Notes: In the non-reduced sample the A chain shifts down toward the B chain following activation.

Natural Human Factor XIIIa protein (ab62412) 使用論文

ab62412 has not yet been referenced specifically in any publications.

Product Wall

Vielen Dank für Ihre Antwort. Leider haben wir aktuell kein aufgereinigtes A chain des Factors XIIIa oder Factors XIII in unserem Katalog. Ich habe auch das Labor die den ab62412 produziert angefragt, ob ein aufgereinigtes A chain erhältich sei,...

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Thank you for your inquiry. Indeed, the protein ab62412, Factor XIIIa, is not recombinantly expressed, but the human purified protein. As expected therefore, the molecular weight is around 70kD. Please see the SDS-Page image in the atta...

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Thank you for contacting us. Activity of the proteins was assayed with a commercially available kit, as described below. (We do not offer the kit in our catalogue). The protein has not, to our knowledge, been used in any kind of functional assa...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"