Native Human Factor XIIIa protein (Active) (ab62412)
Key features and details
- Expression system: Native
- Purity: > 95% Ion Exchange Chromatography
- Active: Yes
- Suitable for: SDS-PAGE
製品の詳細
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製品名
Native Human Factor XIIIa protein (Active) -
生理活性
This product has an activity range of 39 U/mg to 200 U/mg
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精製度
> 95 % Ion Exchange Chromatography.
Plasma FXIIIa was generated by cleavage of homogenous plasma FXIII by alpha-thrombin, in the presence of EDTA. This product was then purified by ion and affinity chromatography. -
発現系
Native -
タンパク質長
Full length protein -
Animal free
No -
由来
Native -
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生物種
Human
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関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab62412 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
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製品の状態
Liquid -
備考
Enzymatic FXIIIa is composed of A2'B2. Ab62412 is the active, enzymatic tetrameric form (A2'B2) in absence of calcium ions. In contrast to the inactive tetrameric FXIII (A2B2), ab62412 has been activated by thrombin.
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 0.0146% EDTA, 50% Glycerol
This product is an active protein and may elicit a biological response in vivo, handle with caution.
関連情報
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別名
- bA525O21.1 (coagulation factor XIII, A1 polypeptide)
- Coagulation factor XIII A chain
- Coagulation factor XIII A1 polypeptide
see all -
機能
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. -
関連疾患
Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. -
配列類似性
Belongs to the transglutaminase superfamily. Transglutaminase family. -
翻訳後修飾
The activation peptide is released by thrombin. -
細胞内局在
Cytoplasm. Secreted. Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma. - Information by UniProt
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プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab62412 は論文での使用が確認できていません。