Native Human FXI protein (ab62538)
Key features and details
- Expression system: Native
- Purity: > 95% Affinity purified
- Suitable for: SDS-PAGE
製品の詳細
-
製品名
Native Human FXI protein -
精製度
> 95 % Affinity purified.
FXI is purified from fresh frozen plasma that is stabilized by added inhibitors. The plasma is first treated with BaCl2 to remove the vitamin K-dependent proteins, and FXI is then isolated by affinity chromatography. A final chromatography step on heparin sepharose yields a homogeneous preparation of intact FXI. -
発現系
Native -
タンパク質長
Full length protein -
Animal free
No -
由来
Native -
-
生物種
Human
-
特性
Our Abpromise guarantee covers the use of ab62538 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
アプリケーション
SDS-PAGE
-
製品の状態
Liquid -
備考
Previously labelled as Factor XI.
-
Concentration information loading...
前処理および保存
-
保存方法および安定性
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 50% Glycerol, 50% Water
50% H2O
関連情報
-
別名
- Coagulation factor XI
- Coagulation factor XIa light chain
- F11
see all -
機能
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. -
組織特異性
Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. -
関連疾患
Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. -
配列類似性
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain. -
翻訳後修飾
Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. -
細胞内局在
Secreted. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (0)
ab62538 は論文での使用が確認できていません。