Natural Human Factor VII protein (ab62386)

製品の概要

製品の詳細

  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab62386 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol

関連情報

  • 別名
    • Coagulation factor VII
    • coagulation factor VII (serum prothrombin conversion accelerator)
    • Eptacog alfa
    • F7
    • FA7_HUMAN
    • Factor VII
    • Factor VII heavy chain
    • Factor VII light chain
    • FVII coagulation protein
    • OTTHUMP00000018733
    • OTTHUMP00000018734
    • Proconvertin
    • Serum prothrombin conversion accelerator
    • SPCA
    see all
  • 機能Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
  • 組織特異性Plasma.
  • 関連疾患Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:227500]. FA7D is a rare hereditary hemorrhagic disease. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Numerous subjects are completely asymptomatic despite a very low F7 level.
  • 配列類似性Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • 翻訳後修飾The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 細胞内局在Secreted.
  • Information by UniProt

Natural Human Factor VII protein (ab62386) 使用論文

ab62386 has not yet been referenced specifically in any publications.

Product Wall

The concentration of our factor VII is obtained by UV, using an extinction coefficient: E 1% 1cm , 280 nm = 13.9.

Thanks for your reply and for your patience. I apologize for the extended delay in getting more information about this protein. My contact at the lab has said that the SDS-PAGE profile of reduced Factor VII and VIIa are distinct. Reduced and non...

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Thank you for your call yesterday and for your patience while I have been in touch with the lab. Based on SDS-PAGE, the Factor VII protein ab62386 does not contain detectable levels of Factor VIIa. I hope this information will be useful...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"