Natural Human Factor V protein (ab62414)

製品の概要

製品の詳細

  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab62414 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 50% H2O

関連情報

  • 別名
    • Activated protein C cofactor
    • APC cofactor
    • Coagulation factor V
    • coagulation factor V (proaccelerin, labile factor)
    • coagulation factor V jinjiang A2 domain
    • Coagulation factor V light chain
    • F5
    • FA5_HUMAN
    • Factor V Leiden
    • FactorV
    • FVL
    • Labile factor
    • PCCF
    • Proaccelerin
    • proaccelerin, labile factor
    • Protein C cofactor
    • RPRGL1
    • THPH2
    see all
  • 機能Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
  • 組織特異性Plasma.
  • 関連疾患Factor V deficiency
    Thrombophilia due to activated protein C resistance
    Budd-Chiari syndrome
    Ischemic stroke
    Pregnancy loss, recurrent, 1
  • 配列類似性Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 2 F5/8 type C domains.
    Contains 6 plastocyanin-like domains.
  • ドメインDomain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
  • 翻訳後修飾Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
    Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
    Activated protein C inactivates factor V and factor Va by proteolytic degradation.
    Phosphorylation sites are present in the extracellular medium.
  • 細胞内局在Secreted.
  • Information by UniProt

Natural Human Factor V protein (ab62414) 使用論文

ab62414 has not yet been referenced specifically in any publications.

Product Wall

Thank you very much for your interest in our proteins. Unfortunately we do currently only have the human and bovine factor V in our catalogue. These are the ab62414 (human) and the ab62236 (bovine). Please let me know if you would like to receive more ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"