Natural human Factor IXa protein (ab81593)
製品の概要
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製品名Natural human Factor IXa protein
Factor IXa タンパク質・ペプチド 製品一覧 -
タンパク質長Full length protein
製品の詳細
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由来Native
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由来Native
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アミノ酸配列
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生物種Human
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領域47 to 461
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特性
Our Abpromise guarantee covers the use of ab81593 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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生理活性<1% Factor IXa activity. Assay is performed to determine percent contaminating IXa activity. IXa activity is based on a IXa standard curve. Chromagenic assay uses Spectrozyme-IXa (American Diagnostica) as substrate. Active site blocked by EGR.
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アプリケーション
SDS-PAGE
Functional Studies
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精製度> 95 % SDS-PAGE.
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製品の状態Liquid
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Preservative: None
Constituents: 20mM HEPES, 150mM Sodium chloride, pH 7.4This product is an active protein and may elicit a biological response in vivo, handle with caution.
関連情報
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別名
- Christmas factor
- Coagulant factor IX
- Coagulation factor IX
see all -
機能Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
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組織特異性Synthesized primarily in the liver and secreted in plasma.
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関連疾患Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis. -
配列類似性Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain. -
ドメインCalcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.
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翻訳後修飾Activated by factor XIa, which excises the activation peptide.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. -
細胞内局在Secreted.
- Information by UniProt
参考文献
This product has been referenced in:
- Fischer M et al. Novel in vitro inhibitory functions of potato tuber proteinaceous inhibitors. Mol Genet Genomics 290:387-98 (2015). Read more (PubMed: 25260821) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"