製品の概要

製品の詳細

  • 由来
    Native
  • 由来
    Native
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      184 kDa
    • 配列の追加情報
      Prepared from Human Placenta and is chromatographically and immunologically pure.

関連製品

特性

Our Abpromise guarantee covers the use of ab7537 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    Collagen taken from human species.
  • アプリケーション

    Western blot

    Immunoprecipitation

    ELISA

  • 製品の状態
    Liquid
  • 備考

    This product is free from other collagens, human serum proteins and non-collagen extracellular matrix proteins. This product reacts with anti-Collagen Type V. Reaction with anti-Collagen I, II, III, IV or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).

    Collagen taken from human species.

    Denaturing and reducing conditions will greatly diminish reactivity and selectivity of this protein.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.01% Sodium azide
    Constituent: 0.06% Acetic acid

関連情報

  • 別名
    • AB collagen
    • Alpha 1 type V collagen
    • Alpha 2 type V collagen
    • CO5A1_HUMAN
    • COL5A1
    • Col5A2
    • COL5A2 protein
    • Col5A3
    • Collagen alpha 1(V) chain
    • Collagen alpha 2 (V) chain precursor
    • Collagen alpha 2(V) chain
    • Collagen alpha 3(V) chain
    • Collagen alpha-1(V) chain
    • Collagen fetal membrane A polypeptide
    • Collagen type V alpha 1
    • Collagen type V alpha 2
    • Collagen type V alpha 3
    • Collagen V alpha 2 polypeptide
    • CollagenV
    • MGC105115
    • OTTHUMP00000064637
    • Pro alpha 1 type V collagen
    • Pro alpha 3(V) collagen
    • Procollagen alpha 2(V)
    • Type V preprocollagen alpha 2 chain
    see all
  • 機能
    Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
  • 関連疾患
    Ehlers-Danlos syndrome 1
    Ehlers-Danlos syndrome 2
  • 配列類似性
    Belongs to the fibrillar collagen family.
    Contains 1 fibrillar collagen NC1 domain.
    Contains 1 laminin G-like domain.
  • ドメイン
    The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
  • 翻訳後修飾
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    Sulfated on 40% of tyrosines.
  • 細胞内局在
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

参考文献

ab7537 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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