製品の概要

製品の詳細

  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab77871 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Specific activity: 541 Units/mg (prior to lyophilization). One unit is the amount of enzyme which digests hemoglobin releasing peptides which are soluble in 10% TCA. The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37ºC. Substrate: Acid denatured hemoglobin (0.2% in reaction mixture). Buffer: 0.1 M formate, pH 3.3.
  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 2mM Sodium phosphate, pH 6.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成Reconstitute with 28.3ul distilled water. Protein: 0.883mg/ml (prior to lyophilization).

関連情報

  • 別名
    • CatD
    • CATD_HUMAN
    • Cathepsin D heavy chain
    • CD
    • Ceroid lipofuscinosis neuronal 10
    • CLN10
    • CPSD
    • ctsd
    • Epididymis secretory sperm binding protein Li 130P
    • HEL S 130P
    • Lysosomal aspartyl peptidase
    • Lysosomal aspartyl protease
    • MGC2311
    see all
  • 機能Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
  • 組織特異性Expressed in the aorta extrcellular space (at protein level).
  • 関連疾患Ceroid lipofuscinosis, neuronal, 10
  • 配列類似性Belongs to the peptidase A1 family.
    Contains 1 peptidase A1 domain.
  • 翻訳後修飾N- and O-glycosylated.
  • 細胞内局在Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
  • Information by UniProt

Natural human Cathepsin D protein (ab77871) 使用論文

This product has been referenced in:
  • Cubedo J  et al. A novel truncated form of apolipoprotein A-I transported by dense LDL is increased in diabetic patients. J Lipid Res 56:1762-73 (2015). Read more (PubMed: 26168996) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab77871.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"