Natural Human C1 Inactivator protein (ab90388)

製品の概要

製品の詳細

  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab90388 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 250mM Sodium chloride, 20mM Potassium phosphate, pH 7.0

関連情報

  • 別名
    • C1 esterase inhibitor
    • C1 Inh
    • C1 inhibiting factor
    • C1 inhibitor
    • C1-inhibiting factor
    • C1IN
    • C1Inh
    • C1NH
    • complement component 1 inhibitor
    • esterase inhibitor
    • HAE1
    • HAE2
    • IC1_HUMAN
    • Plasma protease C1 inhibitor
    • Serine (or cysteine) proteinase inhibitor clade G member 1
    • serine/cysteine proteinase inhibitor clade G member 1
    • Serpin G1
    • serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
    • SERPING1
    see all
  • 機能Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
  • 関連疾患Defects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
  • 配列類似性Belongs to the serpin family.
  • 翻訳後修飾Highly glycosylated (49%) with N- and O-glycosylation.
    Can be proteolytically cleaved by E.coli stcE.
  • 細胞内局在Secreted.
  • Information by UniProt

Natural Human C1 Inactivator protein (ab90388) 使用論文

ab90388 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

I have received word from the supplier about the concentration of this lot of ab90388. The concentration is 11.05mg/ml. The 1mg vial should contain approximately 87ul of solution.

I hope this infor...

Read More

Thank you very much for contacting us.

I just wanted to let you know that I am still working on your inquiry. I have contacted the originator of this product for the information you requested, and I am awaiting a reply.

I am v...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"