Natural human Butyrylcholinesterase protein (ab96367)

製品の概要

製品の詳細

  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • アクセッション番号P06276
    • 生物種Human
    • 分子量65 kDa
    • 領域29 to 602

特性

Our Abpromise guarantee covers the use of ab96367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性

    >100 U/mg.

  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 製品の状態Lyophilised
  • 備考Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies. Butyrylcholinesterase enzyme assay: One unit of Butyrylcholinesterase will hydrolyse 1.0µ mole of Butyrylcholine per min at pH 8.0 at 37°C.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C.

    Preservative: None
    Constituents: 0.02M Ammonium bicarbonate. May contain traces of buffer salts.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成Use of a phosphate buffer pH >7.0 containing 0.15M NaCl is recommended.

関連情報

  • 別名
    • Acylcholine acylhydrolase
    • BCHE
    • Butyrylcholine esterase
    • CHE1
    • CHE2
    • CHLE_HUMAN
    • Choline esterase II
    • Cholinesterase
    • Cholinesterase (serum) 2
    • Cholinesterase 1
    • E1
    • Pseudocholinesterase
    • Pseudocholinesterase E1
    see all
  • 機能Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
  • 組織特異性Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
  • 関連疾患Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
  • 配列類似性Belongs to the type-B carboxylesterase/lipase family.
  • 細胞内局在Secreted.
  • Information by UniProt

Natural human Butyrylcholinesterase protein (ab96367) 使用論文

ab96367 has not yet been referenced specifically in any publications.

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