製品の概要

製品の詳細

  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • アクセッション番号O75787
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab109673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    Prepared from frozen Human plasma using immobilized anti-Human Renin IgG.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • APT6M8 9
    • APT6M8-9
    • ATP6AP2
    • ATP6IP2
    • ATP6M8-9
    • ATPase H(+)-transporting lysosomal accessory protein 2
    • ATPase H(+)-transporting lysosomal-interacting protein 2
    • ATPase H+ transporting lysosomal accessory protein 2
    • ATPase H+ transporting lysosomal interacting protein 2
    • ATPase H+ transporting lysosomal vacuolar proton pump membrane sector associated protein M8 9
    • ATPase membrane sector associated protein M8 9
    • ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8 9
    • CAPER
    • ELDF10
    • Embryonic liver differentiation factor 10
    • ER localized type I transmembrane adaptor
    • ER-localized type I transmembrane adaptor
    • HT028
    • M8 9
    • M8-9
    • MGC99577
    • MRXE
    • MSTP009
    • N14F
    • Renin receptor
    • Renin/prorenin receptor
    • RENR_HUMAN
    • V ATPase M8 9 subunit
    • V ATPase M8.9 subunit
    • V-ATPase M8.9 subunit
    • Vacuolar ATP synthase membrane sector associated protein M8 9
    • Vacuolar ATP synthase membrane sector-associated protein M8-9
    • vacuolar proton ATP synthase membrane sector associated protein M8 9
    • XMRE
    see all
  • 機能Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).
  • 組織特異性Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta.
  • 関連疾患Defects in ATP6AP2 are a cause of mental retardation X-linked with epilepsy (MRXE) [MIM:300423]. MRXE is a syndromic mental retardation. Patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy.
  • 翻訳後修飾Phosphorylated.
  • 細胞内局在Membrane.
  • Information by UniProt

Natural Human ATP6IP2 protein (ab109673) 使用論文

ab109673 has not yet been referenced specifically in any publications.

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