製品の概要

製品の詳細

  • 由来
    Native
  • 由来
    Native
  • アミノ酸配列
    • 生物種
      Human

特性

Our Abpromise guarantee covers the use of ab77944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10mM Ammonium bicarbonate, pH 7.4

  • 再構成
    Reconstitute with 59.9ul distilled water.

関連情報

  • 別名
    • APOC3
    • APO C3
    • Apo CIII
    • Apo-CIII
    • APOC 3
    • ApoC III
    • ApoC-III
    • APOC3
    • APOC3_HUMAN
    • ApoCIII
    • Apolipoprotein C III
    • Apolipoprotein C-III
    • Apolipoprotein C3
    • ApolipoproteinCIII
    • MGC150353
    see all
  • 機能
    Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
  • 組織特異性
    Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
  • 関連疾患
    Defects in APOC3 may be a cause of hyperalphalipoproteinemia (HYPALIP) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).
  • 配列類似性
    Belongs to the apolipoprotein C3 family.
  • 翻訳後修飾
    O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.
  • 細胞内局在
    Secreted.
  • Information by UniProt

画像

  • All lanes : Anti-Apolipoprotein CIII antibody (ab21032) at 1 µg/ml

    Lane 1 : Natural Human Apolipoprotein CIII (ab77944) at 0.1 µg
    Lane 2 : Natural Human Apolipoprotein CIII (ab77944) at 0.01 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 1 minute

参考文献

ab77944 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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