Natural Human Apolipoprotein A I (ab90760)



  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • 生物種Human


Our Abpromise guarantee covers the use of ab90760 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション


  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • 備考Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
  • Concentration information loading...


  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 10mM Ammonium bicarbonate, pH 7.4


  • 別名
    • Apo-AI
    • ApoA I
    • ApoA-I
    • APOA1
    • Apolipoprotein A-I(1-242)
    • Apolipoprotein A1
    • Apolipoprotein AI
    • Brp14
    • Ltw1
    • Lvtw1
    • Sep1
    • Sep2
    see all
  • 機能Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
  • 組織特異性Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine.
  • 関連疾患Defects in APOA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). Inheritance is autosomal dominant.
    Defects in APOA1 are a cause of the low HDL levels observed in high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by the absence of plasma HDL, accumulation of cholesteryl esters, premature coronary artery disease, hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. In HDLD1 patients, ApoA-I fails to associate with HDL probably because of the faulty conversion of pro-ApoA-I molecules into mature chains, either due to a defect in the converting enzyme activity or a specific structural defect in Tangier ApoA-I.
    Defects in APOA1 are the cause of amyloid polyneuropathy-nephropathy Iowa type (AMYLIOWA) [MIM:107680]; also known as amyloidosis van Allen type or familial amyloid polyneuropathy type III. AMYLIOWA is a hereditary generalized amyloidosis due to deposition of amyloid mainly constituted by apolipoprotein A1. The clinical picture is dominated by neuropathy in the early stages of the disease and nephropathy late in the course. Death is due in most cases to renal amyloidosis. Severe peptic ulcer disease can occurr in some and hearing loss is frequent. Cataracts is present in several, but vitreous opacities are not observed.
    Defects in APOA1 are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.
  • 配列類似性Belongs to the apolipoprotein A1/A4/E family.
  • 翻訳後修飾Palmitoylated.
    Phosphorylation sites are present in the extracelllular medium.
  • 細胞内局在Secreted.
  • Information by UniProt

Natural Human Apolipoprotein A I 画像

  • SDS-PAGE analysis of ab90760 on a 4-12% Bis-Tris NuPAGE gel
    Lane 1: Apolipoprotein A I - 5 µg (reduced /heated)
    Lane 2: Apolipoprotein A I - 10 µg (reduced/ heated)
    Lane 3: Apolipoprotein A I - 20 µg (reduced /heated)
    Lane 4: Molecular weight markers
    Lane 5: Apolipoprotein A I - 5 µg (non-reduced/no heat)
    Lane 6: Apolipoprotein A I - 10 µg (non-reduced/no heat)
    Lane 7: Apolipoprotein A I - 20 µg (non-reduced /no heat)

Natural Human Apolipoprotein A I (ab90760) 使用論文

ab90760 has not yet been referenced specifically in any publications.

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We use an A280 reading of a 0.1% solution, 1 cm pathway, and an extinction coefficient of 1.22.

Thank you for your inqury.

We have antibodies that are tested and guaranteed for IHC-Fr and ICC which are the main applictaions for indirect immunofluorescence:

ab52945 ...

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Thank you for contacting us. Yes, the Apolipoprotein A I protein ab90760 is the correct target for the antibodies ab52945 and ab20918. However, please note that the only data we have for sELISA are : - ab52945 has been used in sELISA in pair wi...

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