Natural Human alpha 2 Macroglobulin protein (ab91104)

製品の概要

製品の詳細

  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab91104 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Lyophilised
  • 備考Protein Determination: Extinction Coefficient (E) 0.1% at 280nm, 1cm pathway = 0.81. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20ºC.

    Preservative: None
    Constituents: Glycine, 30mM Sodium phosphate, pH 7.0

関連情報

  • 別名
    • A2m
    • A2MG_HUMAN
    • Alpha 2 M
    • Alpha 2M
    • Alpha-2-M
    • Alpha-2-macroglobulin
    • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
    • CPAMD5
    • DKFZp779B086
    • FWP007
    • S863 7
    see all
  • 機能Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
  • 組織特異性Secreted in plasma.
  • 配列類似性Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
  • 発生段階Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.
  • 細胞内局在Secreted.
  • Information by UniProt

Natural Human alpha 2 Macroglobulin protein 画像

  • SDS-PAGE: 4-12% Bis-Tris-HCl NuPAGE gel
    Lane 1. 5 µg alpha 2 Macroglobulin (non-reduced/no heat)
    Lane 2. 10 µg alpha 2 Macroglobulin (non-reduced/no heat)
    Lane 3. 20 µg alpha 2 Macroglobulin (non-reduced/no heat)
    Lane 4. 5 µg alpha 2 Macroglobulin (reduced/ heated)
    Lane 5. 10 µg alpha 2 Macroglobulin (reduced/ heated)
    Lane 6. 20 µg alpha 2 Macroglobulin (reduced/ heated)
    Lane 7. Molecular weight markers

Natural Human alpha 2 Macroglobulin protein (ab91104) 使用論文

ab91104 has not yet been referenced specifically in any publications.

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