Native Cow Protein C (ab62397)
Key features and details
- Expression system: Native
- Purity: > 95% Ion Exchange Chromatography
- Suitable for: SDS-PAGE, Functional Studies
製品の詳細
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製品名
Native Cow Protein C
Protein C タンパク質・ペプチド 製品一覧 -
精製度
> 95 % Ion Exchange Chromatography.
Prepared by a modification of the Walker procedure as described by Haley et al. Purity is determined by SDS-PAGE analysis -
発現系
Native -
タンパク質長
Full length protein -
Animal free
No -
由来
Native -
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生物種
Cow -
配列の追加情報
Source = fresh citrated bovine plasma
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特性
Our Abpromise guarantee covers the use of ab62397 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
Functional Studies
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製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 50% Glycerol, 50% Water
関連情報
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別名
- Activation peptide
- Anticoagulant protein C
- APC
see all -
機能
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845). -
組織特異性
Plasma; synthesized in the liver. -
関連疾患
Thrombophilia due to protein C deficiency, autosomal dominant
Thrombophilia due to protein C deficiency, autosomal recessive -
配列類似性
Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain. -
翻訳後修飾
The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide. -
細胞内局在
Secreted. Golgi apparatus. Endoplasmic reticulum. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab62397 は論文での使用が確認できていません。