Anti-Natriuretic peptides A 抗体 [M622709] (ab2093)

製品の概要

  • 製品名
    Anti-Natriuretic peptides A antibody [M622709]
    Natriuretic peptides A 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [M622709] to Natriuretic peptides A
  • 特異性
    Affinity Constant: 2.2 x 1010 L/M
  • アプリケーション
    適用あり: Flow Cyt, RIA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Atrial Natriuretic Peptide whole molecule

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab2093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use at an assay dependent concentration. PubMed: 20080656

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

RIA Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
  • 関連疾患
    Atrial standstill 2
    Atrial fibrillation, familial, 6
  • 配列類似性
    Belongs to the natriuretic peptide family.
  • 翻訳後修飾
    Cleaved by CORIN upon secretion to produce the functional hormone.
    Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ANF antibody
    • ANF_HUMAN antibody
    • ANP antibody
    • ATFB6 antibody
    • Atrial natriuretic factor antibody
    • Atrial natriuretic peptide antibody
    • Atriopeptin antibody
    • Cardiodilatin antibody
    • Cardiodilatin related peptide antibody
    • Cardiodilatin-related peptide antibody
    • Cardionatrin antibody
    • CDD ANF antibody
    • CDD antibody
    • CDD-ANF antibody
    • CDP antibody
    • Natriuretic peptide A antibody
    • Natriuretic peptide precursor A antibody
    • NPPA antibody
    • PND antibody
    • Prepronatriodilatin antibody
    see all

参考文献

This product has been referenced in:
  • Therrien JP  et al. A gene therapy approach for long-term normalization of blood pressure in hypertensive mice by ANP-secreting human skin grafts. Proc Natl Acad Sci U S A 107:1178-83 (2010). IHC-P, Flow Cyt ; Human . Read more (PubMed: 20080656) »

See 1 Publication for this product

レビューと Q&A

Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Human Tissue sections (Salivary gland)
Antigen retrieval step
None
Permeabilization
No
Specification
Salivary gland
Blocking step
BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 2000µg/mL · Temperature: 21°C
Fixative
Paraformaldehyde
Username

Dr. Isabelle Miletich

Verified customer

投稿 Jan 05 2017

Abcam has not validated the combination of species/application used in this Abreview.
Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Mouse Tissue sections (Heart tissue including atrium)
Antigen retrieval step
None
Permeabilization
No
Specification
Heart tissue including atrium
Blocking step
BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 2000µg/mL · Temperature: 21D°C
Fixative
Formaldehyde
Username

Dr. Isabelle Miletich

Verified customer

投稿 Nov 04 2016

Thank you for contacting us.


I have attached the CoCs for ab14319, Anti-Urodilatin antibody and for ab2093 Anti-ANP antibody [M622709] as well the SDS for ab2093. I have also asked our documents team to create the SDS for ab14319. This w...

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Thank you for your enquiry. Unfortunately, we do not have the protein that was used to make this antibody in our catalogue and I am afraid that I do not know if it is commercially available. I am sorry I can't be of more assistance in this occas...

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Thank you for your enquiry. ab2093 was generated using Atrial Natriuretic Peptide whole molecule as the immunogen. The peptide sequence has accession number: CAA25700 and the following sequence: MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHL...

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Clone M622709 is subtype IgG1. The approximate molecular weight of IgG1 is 148,000 daltons. This antibody has only been tested for application in Immunohistochemistry (Formalin-fixed paraffin-embedded sections)and Radioimmunoassay.

Thank you for your enquiry and your interest in our products. As my colleagues possibly explained to you over the telephone, this antibody has not been tested for Western blot application. According to the datasheet, ab2093 recognizes the native for...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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