Native Human Serum Albumin protein (FITC) (ab8030)
Key features and details
- Expression system: Native
- Suitable for: Dot blot, WB
製品の詳細
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製品名
Native Human Serum Albumin protein (FITC)
Human Serum Albumin タンパク質・ペプチド 製品一覧 -
発現系
Native -
アクセッション番号
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タンパク質長
Full length protein -
Animal free
No -
由来
Native -
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生物種
Human -
予測される分子量
69 kDa
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標識
FITC. Ex: 493nm, Em: 528nm -
製品の詳細
Native Human Human Serum Albumin protein (FITC)
特性
Our Abpromise guarantee covers the use of ab8030 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Dot blot
Western blot
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製品の状態
Lyophilized -
備考
Fluorochrome/Protein Ratio: 1.5 moles FITC per mole of Human Albumin.
AB8030 contains Polyethylene glycol at 10 mg/mL as a stabilizer.
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at 4°C prior to reconstitution. Store at -20°C long term. Avoid freeze / thaw cycle. Reconstitute for long term storage.
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride, 1% Polyethylene glycol -
再構成Reconstitute with 1.0 mL of deionized water
関連情報
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別名
- alb
- ALBU_HUMAN
- Albumin
see all -
機能
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. -
組織特異性
Plasma. -
関連疾患
Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population. -
配列類似性
Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains. -
翻訳後修飾
Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.
Glycated in diabetic patients.
Phosphorylation sites are present in the extracelllular medium.
Acetylated on Lys-223 by acetylsalicylic acid. -
細胞内局在
Secreted. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab8030 は 9 報の論文で使用されています。
- Sutton MN et al. RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging. Mol Imaging Biol 24:498-509 (2022). PubMed: 34905147
- Liang X et al. Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models. J Extracell Vesicles 11:e12248 (2022). PubMed: 35879268
- Offeddu GS et al. Microphysiological endothelial models to characterize subcutaneous drug absorption. ALTEX N/A:N/A (2022). PubMed: 36533850
- Zhang SY & Mahler GJ Modelling Renal Filtration and Reabsorption Processes in a Human Glomerulus and Proximal Tubule Microphysiological System. Micromachines (Basel) 12:N/A (2021). PubMed: 34442605
- Bres EE et al. Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures. Glia 68:2517-2549 (2020). PubMed: 32579270
- Offeddu GS et al. An on-chip model of protein paracellular and transcellular permeability in the microcirculation. Biomaterials 212:115-125 (2019). PubMed: 31112823
- Offeddu GS et al. Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution. Small 15:e1902393 (2019). PubMed: 31497931
- Zadravec P et al. Development of Recombinant Lactococcus lactis Displaying Albumin-Binding Domain Variants against Shiga Toxin 1 B Subunit. PLoS One 11:e0162625 (2016). ELISA . PubMed: 27606705
- Homan KA et al. Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips. Sci Rep 6:34845 (2016). PubMed: 27725720