製品の概要

  • 製品名
    Native Cyclosporin A protein
  • タンパク質長
    Full length protein

製品の詳細

  • 由来
    Native
  • アミノ酸配列
    • 生物種
      Beauveria
    • 配列
      Chemically, cyclosporin is designated as [R-[R*,R*-(E)]]-cyclic(L-alanyl-D-alanyl-N-methyl- L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydr oxy-N, 4-dimethyl-L-2-amino-6-octenoyl-L-alpha-amino-buty ryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-met hyl-L-leucyl). Molecular Formula: C62H111N11O12.
    • 分子量
      1 kDa
    • 配列の追加情報
      Cyclosporin is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids and having a molecular weight of 1202.64.

特性

Our Abpromise guarantee covers the use of ab73731 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Mass Spectrometry

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None

  • 再構成
    Reconstitute the lyophilized Cyclosporin A in sterile 18Megaohm-cm H2O at not less than 100µg/ml, which can then be further diluted to other aqueous solutions

関連情報

  • 関連性
    Cyclosporin is used to prevent rejection following solid organ and bone marrow transplantation . It has been estimated that cyclosporine is given to more than 90% of children who have received a kidney transplant in the United States. In addition, the ability of cyclosporin to inhibit T-cell activation has been shown to have a role in the treatment of diseases such as nephrotic syndrome, refractory Crohn's disease and ulcerative colitis, biliary cirrhosis, aplastic anemia, rheumatoid arthritis, myasthenia gravis, and dermatomyositis.
  • 細胞内局在
    Cytoplasmic

参考文献

ab73731 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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