Nanos Homologue 1 (NANOS1) peptide (281-292) (ab45711)

製品の概要

  • 製品名Nanos Homologue 1 (NANOS1) peptide (281-292)

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-SARDGPPGKKLR
    • 領域281 to 292

関連製品

特性

Our Abpromise guarantee covers the use of ab45711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-Nanos Homologue 1 (NANOS1) antibody (ab36163)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

関連情報

  • 別名
    • EC Rep1a
    • EC_Rep1a
    • NANO1_HUMAN
    • NANOS 1
    • Nanos homolog 1
    • Nanos homolog 1 (Drosophila)
    • NANOS1
    • Nos 1
    • NOS-1
    • Nos1
    • OTTHUMP00000046853
    • Rep 1a
    • Rep1a
    see all
  • 機能May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
  • 組織特異性Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.
  • 配列類似性Belongs to the nanos family.
    Contains 1 nanos-type zinc finger.
  • 発生段階Fetal ovary and fetal testis (at protein level).
  • ドメインThe Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
    The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction with SNAPIN.
  • 細胞内局在Cytoplasm > perinuclear region. Cytoplasm. Co-localizes with SNAPIN and PUM2 in the perinuclear region of germ cells.
  • Information by UniProt

Nanos Homologue 1 (NANOS1) peptide (281-292) (ab45711) 使用論文

ab45711 has not yet been referenced specifically in any publications.

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