Anti-Nanos Homologue 1 (NANOS1) 抗体 (ab106535)

製品の概要

  • 製品名
    Anti-Nanos Homologue 1 (NANOS1) antibody
    Nanos Homologue 1 (NANOS1) 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Nanos Homologue 1 (NANOS1)
  • アプリケーション
    適用あり: ICC/IF, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide, a 14 aa from near the center of Human Nanos Homologue 1 (NANOS1) (Q8WY41).

  • ポジティブ・コントロール
    • Rat brain lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106535 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 30 kDa.

ターゲット情報

  • 機能
    May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
  • 組織特異性
    Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.
  • 配列類似性
    Belongs to the nanos family.
    Contains 1 nanos-type zinc finger.
  • 発生段階
    Fetal ovary and fetal testis (at protein level).
  • ドメイン
    The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
    The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction with SNAPIN.
  • 細胞内局在
    Cytoplasm > perinuclear region. Cytoplasm. Co-localizes with SNAPIN and PUM2 in the perinuclear region of germ cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EC Rep1a antibody
    • EC_Rep1a antibody
    • NANO1_HUMAN antibody
    • NANOS 1 antibody
    • Nanos homolog 1 (Drosophila) antibody
    • Nanos homolog 1 antibody
    • NANOS1 antibody
    • Nos 1 antibody
    • NOS-1 antibody
    • Nos1 antibody
    • OTTHUMP00000046853 antibody
    • Rep 1a antibody
    • Rep1a antibody
    see all

画像

  • Immunofluorescence of Nanos Homologue 1 (NANOS1) in Human brain tissue with ab106535 at 20 ug/mL.

  • Lane 1 : Anti-Nanos Homologue 1 (NANOS1) antibody (ab106535) at 1 µg/ml
    Lane 2 : Anti-Nanos Homologue 1 (NANOS1) antibody (ab106535) at 2 µg/ml

    Lane 1 : Rat brain lysate
    Lane 2 : Rat brain lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 30 kDa

参考文献

ab106535 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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