製品の概要

  • 製品名
    NAN-190 hydrobromide
  • 製品の詳細
    Potent 5-HT1A antagonist
  • 生理活性の詳細
    Potent 5-HT1A receptor antagonist (Ki = 6.8 nM). Also displays activity at α2 adrenoceptors. Displays anxiogenic and anxiolytic effects. Additionally, potentiates circadian rhythm response to light.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Foong JP & Bornstein JC 5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig. Neuroreport 20:325-30 (2009). Read more (PubMed: 19190523) »
  • Kessler EJ  et al. NAN-190 potentiates the circadian response to light and speeds re-entrainment to advanced light cycles. Neuroscience 154:1187-94 (2008). Read more (PubMed: 18538936) »
  • Yoshino T & Yamaguchi I Possible involvement of 5-HT2 receptor activation in aggravation of diet-induced acute pancreatitis in mice. J Pharmacol Exp Ther 283:1495-502 (1997). Read more (PubMed: 9400026) »

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