製品の概要

  • 製品名Anti-NALP2 antibody
    NALP2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to NALP2
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to 12 amino acids near the C terminus of Human NALP2 (NP_060322.1).

  • ポジティブ・コントロール
    • Human Brain Cortex tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115614 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 121 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • 組織特異性Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
  • 配列類似性Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • ドメインThe DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.
    When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CLR19.9 antibody
    • FLJ20510 antibody
    • Leucine rich repeat and PYD containing protein 2 antibody
    • LRR and PYD domains-containing protein 2 antibody
    • NACHT antibody
    • NACHT domain antibody
    • NACHT leucine rich repeat and PYD containing 2 antibody
    • NACHT LRR and PYD domains containing protein 2 antibody
    • NALP2 antibody
    • NALP2_HUMAN antibody
    • NBS1 antibody
    • NLR family pyrin domain containing 2 antibody
    • NLRP2 antibody
    • Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2 antibody
    • Nucleotide-binding site protein 1 antibody
    • PAN1 antibody
    • PYPAF2 antibody
    • PYRIN containing APAF1 like protein2 antibody
    • PYRIN domain and NACHT domain-containing protein 1 antibody
    • PYRIN-containing APAF1-like protein 2 antibody
    see all

Anti-NALP2 antibody 画像

  • ab115614, at 5µg/ml, staining NLRP2 in Formalin-fixed, Paraffin-embedded Human brain cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-NALP2 antibody (ab115614) 使用論文

ab115614 has not yet been referenced specifically in any publications.

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