製品の概要

  • 製品名Anti-NALP12 antibody
    NALP12 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to NALP12
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-110 of Human NALP12

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab57906 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
    • 組織特異性Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
    • 関連疾患Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.
    • 配列類似性Belongs to the NLRP family.
      Contains 1 DAPIN domain.
      Contains 8 LRR (leucine-rich) repeats.
      Contains 1 NACHT domain.
    • 細胞内局在Cytoplasm.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CLR19.3 antibody
      • FCAS2 antibody
      • Monarch 1 antibody
      • Monarch-1 antibody
      • NACHT, leucine rich repeat and PYD containing 12 antibody
      • NACHT, LRR and PYD containing protein 12 antibody
      • NACHT, LRR and PYD domains-containing protein 12 antibody
      • NAL12_HUMAN antibody
      • NLR family, pyrin domain containing 12 antibody
      • NLRP12 antibody
      • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 antibody
      • OTTHUMP00000067227 antibody
      • PAN6 antibody
      • PYPAF7 antibody
      • PYRIN containing APAF1 like protein 7 antibody
      • PYRIN-containing APAF1-like protein 7 antibody
      • Regulated by nitric oxide antibody
      • RNO antibody
      • RNO2 antibody
      see all

    Anti-NALP12 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab57906 NALP12 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    Anti-NALP12 antibody (ab57906) 使用論文

    This product has been referenced in:
    • Ataide MA  et al. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog 10:e1003885 (2014). Read more (PubMed: 24453977) »

    See 1 Publication for this product

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    There are currently no Abreviews or Questions for ab57906.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"