生理活性の詳細α1 Adrenoceptor antagonist. pKi values are 3.7, 20 and 1.2 for α1a, α1b and α1d, respectively. Orally active. Implicated in benign prostate hyperplasia and bladder obstruction. Antihypertensive.
保存方法Store at Room Temperature. The product can be stored for up to 12 months.
溶解性Soluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Kanda H et al. Naftopidil, a selective alpha-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest. Int J Cancer122:444-51 (2008).
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Takei R et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol79:447-54 (1999).
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Yamada S et al. Binding characteristics of naftopidil and alpha 1-adrenoceptor antagonists to prostatic alpha-adrenoceptors in benign prostatic hypertrophy. Life Sci50:127-35 (1992).
Read more (PubMed: 1370569) »