製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to MYSM1
  • アプリケーション
    適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Horse, Cow, Chimpanzee, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region between amino acids 700-750 of Human MYSM1 (NP_001078956.1).

  • ポジティブ・コントロール
    • Jurkat whole cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110109 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 2-5 µg/mg of lysate.
  • 追加情報
    Is unsuitable for WB.
  • ターゲット情報

    • 機能
      Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
    • 配列類似性
      Belongs to the peptidase M67A family. MYSM1 subfamily.
      Contains 1 MPN (JAB/Mov34) domain.
      Contains 1 SANT domain.
      Contains 1 SWIRM domain.
    • ドメイン
      Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.
    • 翻訳後修飾
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在
      Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 2A-DUB antibody
      • 2ADUB antibody
      • Histone H2A deubiquitinase antibody
      • Histone H2A deubiquitinase MYSM1 antibody
      • KIAA1915 antibody
      • Myb like SWIRM and MPN domains 1 antibody
      • Myb like, SWIRM and MPN domain containing protein antibody
      • Myb like, SWIRM and MPN domains 1 antibody
      • Myb-like antibody
      • Myb-like, SWIRM and MPN domains 1 antibody
      • MYSM 1 antibody
      • mysm1 antibody
      • MYSM1 Myb-like, SWIRM and MPN domains 1 antibody
      • MYSM1_HUMAN antibody
      • RP4-592A1.1 antibody
      • SWIRM and MPN domain-containing protein 1 antibody
      see all

    画像

    • Detection of MYSM1 in Immunoprecipitates of Jurkat whole cell lysate (1 mg for IP, 20% of IP loaded) using ab110109 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-MYSM1 antibody which recognizes an upstream epitope was used at 1 µg/ml. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.

    プロトコール

    参考文献

    ab110109 has not yet been referenced specifically in any publications.

    レビューと Q&A

    There are currently no Customer reviews or Questions for ab110109.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    登録