製品の概要
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製品名Anti-MYSM1 antibody
MYSM1 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to MYSM1
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アプリケーション適用あり: IPmore details
適用なし: WB -
種交差性交差種: Human
交差が予測される動物種: Horse, Cow, Chimpanzee, Gorilla, Orangutan, Elephant
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免疫原
Synthetic peptide, corresponding to a region between amino acids 700-750 of Human MYSM1 (NP_001078956.1).
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ポジティブ･コントロール
- Jurkat whole cell lysate
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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バッファーPreservative: 0.09% Sodium Azide
Constituents: Tris citrate/phosphate, pH 7-8 -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab110109 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IP | Use at 2-5 µg/mg of lysate. |
追加情報
Is unsuitable for WB.
ターゲット情報
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機能Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
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配列類似性Belongs to the peptidase M67A family. MYSM1 subfamily.
Contains 1 MPN (JAB/Mov34) domain.
Contains 1 SANT domain.
Contains 1 SWIRM domain. -
ドメインBinds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.
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翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
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細胞内局在Nucleus.
- Information by UniProt
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参照データベース
- Entrez Gene: 114803 Human
- Omim: 612176 Human
- SwissProt: Q5VVJ2 Human
- Unigene: 477495 Human
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別名
- 2A-DUB antibody
- 2ADUB antibody
- Histone H2A deubiquitinase antibody
see all
Anti-MYSM1 antibody 画像
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Immunoprecipitation - MYSM1 antibody (ab110109)Detection of MYSM1 in Immunoprecipitates of Jurkat whole cell lysate (1 mg for IP, 20% of IP loaded) using ab110109 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-MYSM1 antibody which recognizes an upstream epitope was used at 1 µg/ml. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.
Anti-MYSM1 antibody (ab110109) 使用論文
ab110109 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"