Anti-Myosin, smooth muscle heavy chain 1 and 2 抗体 [SMMS-1] (ab106919)


  • 製品名Anti-Myosin, smooth muscle heavy chain 1 and 2 antibody [SMMS-1]
    Myosin, smooth muscle heavy chain 1 and 2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [SMMS-1] to Myosin, smooth muscle heavy chain 1 and 2
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Crude Human uterus extract

  • ポジティブ・コントロール
    • Uterus or normal breast tissue. Some breast cancers, leiomyosarcoma.



Our Abpromise guarantee covers the use of ab106919 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/200. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.


  • 機能Muscle contraction.
  • 組織特異性Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea.
  • 関連疾患Note=A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.
    Defects in MYH11 are the cause of aortic aneurysm familial thoracic type 4 (AAT4) [MIM:132900]; also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content.
  • 配列類似性Contains 1 IQ domain.
    Contains 1 myosin head-like domain.
  • ドメインThe rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
    Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
  • 細胞内局在Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AAT4 antibody
    • DKFZp686D10126 antibody
    • DKFZp686D19237 antibody
    • FAA4 antibody
    • FLJ35232 antibody
    • KIAA0866 antibody
    • MGC126726 antibody
    • MGC32963 antibody
    • MYH11 antibody
    • MYH11_HUMAN antibody
    • Myosin heavy chain 11 antibody
    • Myosin heavy chain 11 smooth muscle antibody
    • Myosin heavy chain antibody
    • Myosin heavy chain smooth muscle isoform antibody
    • Myosin heavy polypeptide 11 smooth muscle antibody
    • Myosin-11 antibody
    • SM1 antibody
    • SM2 antibody
    • SMHC antibody
    • SMMHC antibody
    • smooth muscle isoform antibody
    • Smooth muscle myosin heavy chain 11 antibody
    see all

Anti-Myosin, smooth muscle heavy chain 1 and 2 antibody [SMMS-1] (ab106919) 使用論文

This product has been referenced in:
  • Nicolas MM  et al. Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases. Hum Pathol 41:663-71 (2010). Read more (PubMed: 20004935) »

See 1 Publication for this product

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (human smooth muscle cells)
Specification human smooth muscle cells
Fixative Formaldehyde; Methanol; paraformaldehyde
Permeabilization Yes - Triton
Blocking step BSA/Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C

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投稿 Feb 10 2012

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