製品の概要

  • 製品名Anti-Myosin Phosphatase antibody
    Myosin Phosphatase 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Myosin Phosphatase
  • アプリケーション適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rabbit, Cow, Pig, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region between residues 400 and 450 of human Myosin Phosphatase (NP_002471.1)

  • ポジティブ・コントロール
    • Whole cell lysate from HeLa cells.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab70806 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 2-5 µg/mg of lysate.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Regulates myosin phosphatase activity.
    • 組織特異性Expressed in striated muscles, specifically in type 2a fibers (at protein level).
    • 配列類似性Contains 6 ANK repeats.
    • 発生段階Induced by 2-fold during pregnancy, including in abdominus rectus muscle.
    • ドメインHeterotetramerization is mediated by the interaction between a coiled-coil of PRKG1 and the leucine/isoleucine zipper of PPP1R12A/MBS, the myosin-binding subunit of the myosin phosphatase.
    • 翻訳後修飾Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR.
      In vitro, phosphorylation of Ser-695 by PKA and PKG appears to prevent phosphorylation of the inhibitory site Thr-696, probably mediated by PRKG1.
    • 細胞内局在Cytoplasm. Along actomyosin filaments and stress fibers.
    • Information by UniProt
    • 参照データベース
    • 別名
      • M130 antibody
      • MBS antibody
      • Myosin binding subunit antibody
      • Myosin phosphatase target subunit 1 antibody
      • Myosin phosphatase targeting subunit 1 antibody
      • Myosin phosphatase-targeting subunit 1 antibody
      • MYPT1 antibody
      • MYPT1_HUMAN antibody
      • PPP1R12A antibody
      • Protein phosphatase 1 regulatory inhibitor subunit 12A antibody
      • Protein phosphatase 1 regulatory subunit 12A antibody
      • Protein phosphatase 1, regulatory (inhibitor) subunit 12A antibody
      • Protein phosphatase myosin binding subunit antibody
      • Protein phosphatase myosin-binding subunit antibody
      see all

    Anti-Myosin Phosphatase antibody (ab70806) 使用論文

    ab70806 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab70806.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"