製品の概要

  • 製品名Anti-Myosin light chain 3 antibody [MLM544]
    Myosin light chain 3 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MLM544] to Myosin light chain 3
  • 特異性This antibody reacts with ventricle myosin light chain I. Reactivity Human ventricle myosin light chain I - 100% Human ventricle myosin light chain II - < 10% Human atrial myosin light chain I - < 1% Human atrial myosin light chain II - < 5% Human skeletal muscle myosin light chain - < 20% Human smooth muscle myosin light chain - < 0.1% Assay was performed in combination with MLM544 and MLM508
  • アプリケーション適用あり: ELISAmore details
  • 種交差性
    交差種: Rat, Cow, Human, Pig
  • 免疫原

    Human ventricle myosin light chain I.

  • 特記事項

    Can be used as a standard in an ELISA for the anti-myosin light chain 3 antibody, ab678.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab677 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent concentration.

ターゲット情報

  • 機能Regulatory light chain of myosin. Does not bind calcium.
  • 関連疾患Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8) [MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.
    Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
  • 配列類似性Contains 3 EF-hand domains.
  • 翻訳後修飾The N-terminus is blocked.
    N-terminus is methylated by METTL11A/NTM1.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cardiac myosin light chain 1 antibody
    • CMH8 antibody
    • CMLC1 antibody
    • ELC of myosin antibody
    • Essential light chain of myosin antibody
    • MLC1SB antibody
    • MLC1V antibody
    • MYL3 antibody
    • MYL3_HUMAN antibody
    • Myosin light chain 1 antibody
    • Myosin light chain 1 slow twitch muscle B/ventricular isoform antibody
    • Myosin light chain 1 slow, B antibody
    • Myosin light chain 3 antibody
    • Myosin, light chain 1, ventricular antibody
    • myosin, light chain 3, alkali; ventricular, skeletal, slow antibody
    • myosin, light polypeptide 3, alkali antibody
    • myosin, light polypeptide 3, alkali; ventricular, skeletal, slow antibody
    • OTTHUMP00000165922 antibody
    • Slow skeletal ventricular myosin alkali light chain 3 antibody
    • slow-twitch muscle B/ventricular isoform antibody
    • Ventricular/slow twitch myosin alkali light chain antibody
    • VLC1 antibody
    see all

Anti-Myosin light chain 3 antibody [MLM544] 画像

  • ELISA - cardiac Myosin light chain 1 antibody [MLM544] (ab677)

    Coat tube with ab677
    Wash 2 times
    Block with BSA-PBS
    Add sample or standard (porcine cardiac myosin light chain I - ab676)
    Add 125I-labeled MLM508
    Incubate for 18 (12-24) h at 20 (10-20) °C
    Wash 2 times
    Measure radioactivity.

Anti-Myosin light chain 3 antibody [MLM544] (ab677) 使用論文

This product has been referenced in:
  • Katoh H  et al. Development of an immunoradiometric assay kit for ventricular myosin light chain I with monoclonal antibodies. Clin Chem 38:170-1 (1992). Read more (PubMed: 1733600) »

See 1 Publication for this product

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