製品の概要

  • 製品名Anti-Myocilin antibody
    Myocilin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Myocilin
  • 特異性The antibody does not cross react with any other protein in RPE cells.
  • アプリケーション適用あり: WB, IP, Immunomicroscopymore details
  • 種交差性
    交差種: Mouse, Rat, Human, Monkey
  • 免疫原

    Synthetic peptide:

    CLVWDVGARTAQLRKANDQSGR

    conjugated to KLH, corresponding to N terminal amino acids 25/46 of Myocilin

  • ポジティブ・コントロール
    • RPE cell extracts.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab41552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa).
IP 1/200.
Immunomicroscopy Use at an assay dependent dilution.

ターゲット情報

  • 機能May participate in the obstruction of fluid outflow in the trabecular meshwork.
  • 組織特異性Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma.
  • 関連疾患Defects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A) [MIM:137750]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
    Defects in MYOC may also contribute to primary congenital glaucoma type 3A (GLC3A) [MIM:231300]. Defects in MYOC may contribute to this phenotype via digenic inheritance. GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
  • 配列類似性Contains 1 olfactomedin-like domain.
  • 翻訳後修飾Different isoforms may arise by post-translational modifications.
    Glycosylated.
    Palmitoylated.
  • 細胞内局在Rough endoplasmic reticulum. Secreted. Cell projection > cilium. Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. Also secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • GLC1A antibody
    • GPOA antibody
    • JOAG antibody
    • JOAG1 antibody
    • Mutated trabecular meshwork-induced glucocorticoid response protein antibody
    • MYOC antibody
    • MYOC_HUMAN antibody
    • Myocilin antibody
    • Myocilin, trabecular meshwork inducible glucocorticoid antibody
    • TIGR antibody
    • Trabecular meshwork induced glucocorticoid response protein antibody
    • Trabecular meshwork-induced glucocorticoid response protein antibody
    see all

Anti-Myocilin antibody (ab41552) 使用論文

ab41552 has not yet been referenced specifically in any publications.

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