製品の概要

  • 製品名Anti-MYLK2 antibody - N-terminal
    MYLK2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MYLK2 - N-terminal
  • アプリケーション適用あり: ELISA, IHC-P, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide from the N-terminal region of human MYLK2 conjugated to KLH

  • ポジティブ・コントロール
    • Jurkat cell lysate. Human hepatocarcinoma tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab71827 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
IHC-P 1/50 - 1/100.
WB 1/100 - 1/500. Detects a band of approximately 55 kDa (predicted molecular weight: 65 kDa).

ターゲット情報

  • 機能Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
  • 組織特異性Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
  • 関連疾患Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 配列類似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 細胞内局在Cytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
  • Information by UniProt
  • 参照データベース
  • 別名
    • KMLC antibody
    • MLCK antibody
    • MLCK, skeletal/cardiac antibody
    • MLCK2 antibody
    • MYLK 2 antibody
    • MYLK2 antibody
    • MYLK2_HUMAN antibody
    • Myosin light chain kinase 2 antibody
    • Myosin light chain kinase 2 skeletal muscle antibody
    • Myosin light chain kinase 2 skeletal/cardiac muscle antibody
    • MYOSIN LIGHT POLYPEPTIDE KINASE antibody
    • Myosin light polypeptide kinase, skeletal/cardiac antibody
    • Skeletal muscle myosin light chain kinase antibody
    • Skeletal myosin light chain kinase antibody
    • skeletal/cardiac muscle antibody
    • skMLCK antibody
    see all

Anti-MYLK2 antibody - N-terminal 画像

  • Anti-MYLK2 antibody - N-terminal (ab71827) at 1/100 dilution + Jurkat cell lysate at 12.5 µg

    Secondary
    HRP-anti-rabbit

    Predicted band size : 65 kDa
    Observed band size : 55 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 100 kDa,32 kDa,35 kDa,40 kDa. We are unsure as to the identity of these extra bands.
  • ab71827 at 1/50 dilution, staining MYLK2 in human hepatocarcinoma by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and AEC staining.

Anti-MYLK2 antibody - N-terminal (ab71827) 使用論文

ab71827 has not yet been referenced specifically in any publications.

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