製品の概要

  • 製品名Anti-MYH2 antibody [EPR5280]
    MYH2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR5280] to MYH2
  • アプリケーション適用あり: WBmore details
    適用なし: IHC-P or IP
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)

  • ポジティブ・コントロール
    • Mouse muscle, Rat muscle and Human trachea lysates
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab124937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/10000 - 1/50000. Detects a band of approximately 220 kDa (predicted molecular weight: 223 kDa).
  • 追加情報Is unsuitable for IHC-P or IP.
  • ターゲット情報

    • 機能Muscle contraction. Required for cytoskeleton organization.
    • 関連疾患Defects in MYH2 are the cause of inclusion body myopathy type 3 (IBM3) [MIM:605637]. Hereditary inclusion body myopathies constitute a group of neuromuscular disorders characterized by slowly progressive distal and proximal weakness and a typical muscle pathology including rimmed vacuoles and filamentous inclusions. IBM3 is a variant of hereditary inclusion body myopathies and is characterized by autosomal dominant myopathy with joint contracture, ophthalmoplegia and rimmed vacuoles. Morphological analysis of muscle biopsies from patients indicate that the type 2A fibers frequently were abnormal, whereas other fiber types appeared normal.
    • 配列類似性Contains 1 IQ domain.
      Contains 1 myosin head-like domain.
    • ドメインThe rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
      Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
    • 細胞内局在Cytoplasm > myofibril. Thick filaments of the myofibrils.
    • Information by UniProt
    • 参照データベース
    • 別名
      • adult 2 antibody
      • Fast 2a myosin heavy chain antibody
      • IBM3 antibody
      • Inclusion body myopathy 3, autosomal dominant antibody
      • MYH2 antibody
      • MYH2_HUMAN antibody
      • MYH2A antibody
      • MYHas8 antibody
      • MyHC IIa antibody
      • MyHC-2a antibody
      • MyHC-IIa antibody
      • MYHSA2 antibody
      • Myosin heavy chain 2 antibody
      • Myosin heavy chain 2a antibody
      • Myosin heavy chain antibody
      • Myosin heavy chain IIa antibody
      • Myosin heavy chain skeletal muscle adult 2 antibody
      • Myosin heavy polypeptide 2 skeletal muscle adult antibody
      • Myosin-2 antibody
      • MYPOP antibody
      • skeletal muscle antibody
      • Type IIA myosin heavy chain antibody
      see all

    Anti-MYH2 antibody [EPR5280] 画像

    • All lanes : Anti-MYH2 antibody [EPR5280] (ab124937) at 1/10000 dilution

      Lane 1 : Mouse muscle lysate
      Lane 2 : Rat muscle lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled Goat anti Rabbit IgG at 1/2000 dilution

      Predicted band size : 223 kDa
      Observed band size : 220 kDa (why is the actual band size different from the predicted?)
    • Anti-MYH2 antibody [EPR5280] (ab124937) at 1/10000 dilution + Human trachea lysate at 10 µg

      Secondary
      HRP labelled Goat anti Rabbit IgG at 1/2000 dilution

      Predicted band size : 223 kDa
      Observed band size : 220 kDa (why is the actual band size different from the predicted?)
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-MYH2 antibody [EPR5280] (ab124937) 使用論文

    ab124937 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab124937.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"