The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Suitable for immunoblotting (western or dot blot), ELISA and most immunological methods requiring high titer and specificity. Optimal titers for applications should be determined by the researcher.
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.