Anti-Myeloid leukemia factor 1 抗体 (ab103099)

製品の概要

  • 製品名Anti-Myeloid leukemia factor 1 antibody
    Myeloid leukemia factor 1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Myeloid leukemia factor 1
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 222-252 of Human Myeloid leukemia factor 1

  • ポジティブ・コントロール
    • Mouse heart tissue, Human testis carcinoma

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab103099 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 31 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
  • 組織特異性Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
  • 関連疾患Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
  • 配列類似性Belongs to the MLF family.
  • 翻訳後修飾Phosphorylation is required for binding to YWHAZ.
  • 細胞内局在Cytoplasm. Nucleus. In non-hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Hls7 antibody
    • MLF1 antibody
    • MLF1_HUMAN antibody
    • Myelodysplasia myeloid leukemia factor 1 antibody
    • Myelodysplasia-myeloid leukemia factor 1 antibody
    • Myeloid leukemia factor 1 antibody
    • myeloid leukemia factor 1 variant 1 antibody
    • myeloid leukemia factor 1 variant 2 antibody
    • myeloid leukemia factor 1 variant 3 antibody
    see all

Anti-Myeloid leukemia factor 1 antibody 画像

  • Anti-Myeloid leukemia factor 1 antibody (ab103099) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

    Predicted band size : 31 kDa
  • IHC analysis in formalin fixed and paraffin embedded Human testis carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining, using ab103099 at a dilution of 1/50.

Anti-Myeloid leukemia factor 1 antibody (ab103099) 使用論文

ab103099 has not yet been referenced specifically in any publications.

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