Anti-Myelin PLP 抗体 (ab28486)
Key features and details
- Rabbit polyclonal to Myelin PLP
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Myelin PLP antibody
Myelin PLP 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Myelin PLP -
由来種
Rabbit -
特異性
ab28486 recognises PLP -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Mouse
交差が予測される動物種: Cow, Dog, Pig, Macaque monkey -
免疫原
Synthetic peptide:
CG KGLSATVTGG QKGRGSRG
, corresponding to amino acids 109-128 of Mouse Myelin PLP -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.05% Sodium azide
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab28486の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P | (2) |
Use at an assay dependent concentration.
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特記事項 |
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IHC-P
Use at an assay dependent concentration. |
ターゲット情報
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機能
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. -
関連疾患
Defects in PLP1 are the cause of leukodystrophy hypomyelinating type 1 (HLD1) [MIM:312080]; also known as Pelizaeus-Merzbacher disease. HLD1 is an X-linked recessive dysmyelinating disorder of the central nervous system in which myelin is not formed properly. It is characterized clinically by nystagmus, spastic quadriplegia, ataxia, and developmental delay.
Defects in PLP1 are the cause of spastic paraplegia X-linked type 2 (SPG2) [MIM:312920]. SPG2 is characterized by spastic gait and hyperreflexia. In some patients, complicating features include nystagmus, dysarthria, sensory disturbance, mental retardation, optic atrophy. -
配列類似性
Belongs to the myelin proteolipid protein family. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 281410 Cow
- Entrez Gene: 481002 Dog
- Entrez Gene: 18823 Mouse
- SwissProt: P04116 Cow
- SwissProt: P23294 Dog
- SwissProt: P60202 Mouse
- Unigene: 1268 Mouse
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別名
- HLD1 antibody
- Lipophilin antibody
- Major myelin proteolipid protein antibody
see all
画像
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Immunohistochemical staining of Myelin PLP in mouse brain thick section using ab28486 (1/1000 dilution). Staining (m) is limited to myelin tracts and oligodendrocytes.
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ab28486 at a 1/1000 dilution staining mouse brain (white matter) by IHC-P. The tissue was fixed in 10% formalin saline. Antigen retrieval was via hydrated autoclaving at 121°C for 15 minutes followed by 5 minutes in 98%formic acid. The antibody was incubated with the tissue for 16 hours and then bound antibody was detected using a biotinylated goat anti-rabbit IgG Fc.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (78)
ab28486 は 78 報の論文で使用されています。
- McNamara NB et al. Microglia regulate central nervous system myelin growth and integrity. Nature 613:120-129 (2023). PubMed: 36517604
- Yoon H et al. Blocking Kallikrein 6 promotes developmental myelination. Glia 70:430-450 (2022). PubMed: 34626143
- Zhang P et al. Activation of spinal ephrin-B3/EphBs signaling induces hyperalgesia through a PLP-mediated mechanism. Fundam Clin Pharmacol 36:262-276 (2022). PubMed: 34904278
- Filiou MD et al. Multi-Omics Analysis Reveals Myelin, Presynaptic and Nicotinate Alterations in the Hippocampus of G72/G30 Transgenic Mice. J Pers Med 12:N/A (2022). PubMed: 35207732
- Wan T et al. Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice. Nat Commun 13:1134 (2022). PubMed: 35241660