製品の概要

  • 製品名
    Mycophenolic acid
  • 製品の詳細
    Immunosuppressant. Inosine monophosphate dehydrogenase inhibitor.
  • 生理活性の詳細
    Potent inosine monophosphate dehydrogenase inhibitor (IMPDH) (Ki values are 11 and 6 nM at IMPDH type I and II, respectively). Decreases RNA and DNA synthesis. Immunosuppressive agent. Shows antiviral and antitumor effects in vitro and in vivo.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Morath C  et al. Antifibrotic actions of mycophenolic acid. Clin Transplant 20 Suppl 17:25-9 (2006). Read more (PubMed: 17100698) »
  • Catapano CV  et al. GTP depletion induced by IMP dehydrogenase inhibitors blocks RNA-primed DNA synthesis. Mol Pharmacol 47:948-55 (1995). Read more (PubMed: 7746281) »
  • Hager PW  et al. Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding. Biochem Pharmacol 49:1323-9 (1995). Read more (PubMed: 7763314) »

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