Anti-MYCBP2 抗体 (ab86078)
Key features and details
- Rabbit polyclonal to MYCBP2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-MYCBP2 antibody
MYCBP2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to MYCBP2 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla -
免疫原
Synthetic peptide corresponding to Human MYCBP2 aa 2400-2500.
Database link: O75592 -
ポジティブ・コントロール
- HeLa whole cell lysate (ab150035).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab86078の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (1) |
1/2000 - 1/10000. Predicted molecular weight: 510 kDa.
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特記事項 |
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WB
1/2000 - 1/10000. Predicted molecular weight: 510 kDa. |
ターゲット情報
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関連性
MYCBP2 belongs to the highwire family. It is a probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. MYCBP2 may function as a facilitator or regulator of transcriptional activation by MYC and have a role during synaptogenesis. There are two different isoforms. -
細胞内局在
Nuclear -
参照データベース
- Entrez Gene: 23077 Human
- Entrez Gene: 105689 Mouse
- Entrez Gene: 290447 Rat
- Omim: 610392 Human
- SwissProt: O75592 Human
- SwissProt: Q7TPH6 Mouse
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別名
- AU023734 antibody
- AW107953 antibody
- AW546647 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (12)
ab86078 は 12 報の論文で使用されています。
- Romano D et al. Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma. Life Sci Alliance 5:N/A (2022). PubMed: 36038253
- Ma S et al. MiR-26b-5p inhibits cell proliferation and EMT by targeting MYCBP in triple-negative breast cancer. Cell Mol Biol Lett 26:52 (2021). PubMed: 34895159
- Wang Y et al. NEDD4L-mediated LTF protein degradation limits ferroptosis. Biochem Biophys Res Commun 531:581-587 (2020). PubMed: 32811647
- Mabbitt PD et al. Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity. Nat Chem Biol 16:1227-1236 (2020). PubMed: 32747811
- Qian J et al. lncRNA LUNAR1 accelerates colorectal cancer progression by targeting the miR-495-3p/MYCBP axis. Int J Oncol 57:1157-1168 (2020). PubMed: 33300052