製品の概要

  • 製品名Anti-MYBPC3 antibody [EPR3008(2)]
    MYBPC3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR3008(2)] to MYBPC3
  • アプリケーション適用あり: WBmore details
    適用なし: Flow Cyt,ICC/IF or IHC-P
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human MYBPC3 aa 100-200. The exact sequence is proprietary.

  • ポジティブ・コントロール
    • WB: Human heart tissue lysate.
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated ‘PUR’ on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーpH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 40% Glycerol, 0.05% BSA, 59% PBS
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノモノクローナル
  • クローン名EPR3008(2)
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab108522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 141 kDa.
  • 追加情報Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • ターゲット情報

    • 機能Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
    • 関連疾患Defects in MYBPC3 are the cause of cardiomyopathy familial hypertrophic type 4 (CMH4) [MIM:115197]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • 配列類似性Belongs to the immunoglobulin superfamily. MyBP family.
      Contains 3 fibronectin type-III domains.
      Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
    • 翻訳後修飾Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction.
    • Information by UniProt
    • 参照データベース
    • 別名
      • C protein cardiac muscle isoform antibody
      • C-protein antibody
      • cardiac muscle isoform antibody
      • Cardiac MyBP C antibody
      • Cardiac MyBP-C antibody
      • cardiac-type antibody
      • MYBPC3 antibody
      • myosin binding protein C cardiac antibody
      • Myosin binding protein C cardiac type antibody
      • Myosin-binding protein C antibody
      • MYPC3_HUMAN antibody
      see all

    Anti-MYBPC3 antibody [EPR3008(2)] 画像

    • Anti-MYBPC3 antibody [EPR3008(2)] (ab108522) at 1/5000 dilution (purified) + Human heart tissue lysate at 10 µg

      Secondary
      Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/20000 dilution

      Predicted band size : 141 kDa
      Observed band size : 141 kDa

      Blocking and dilution buffer: 5% NFDM /TBST.

    • Anti-MYBPC3 antibody [EPR3008(2)] (ab108522) at 1/1000 dilution (unpurified) + Human heart tissue lysate at 10 µg

      Predicted band size : 141 kDa

    Anti-MYBPC3 antibody [EPR3008(2)] (ab108522) 使用論文

    ab108522 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab108522.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"