Anti-MYBPC3 抗体 [EPR3008(2)] (ab108522)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR3008(2)] to MYBPC3
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
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製品名
Anti-MYBPC3 antibody [EPR3008(2)]
MYBPC3 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR3008(2)] to MYBPC3 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: Flow Cyt,ICC/IF or IHC-P -
種交差性
交差種: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ・コントロール
- WB: Human heart tissue lysate.
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 0.05% BSA, 59% PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR3008(2) -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab108522の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 141 kDa.
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特記事項 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 141 kDa. |
ターゲット情報
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機能
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. -
関連疾患
Defects in MYBPC3 are the cause of cardiomyopathy familial hypertrophic type 4 (CMH4) [MIM:115197]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. -
配列類似性
Belongs to the immunoglobulin superfamily. MyBP family.
Contains 3 fibronectin type-III domains.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains. -
翻訳後修飾
Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction. - Information by UniProt
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参照データベース
- Entrez Gene: 4607 Human
- Omim: 600958 Human
- SwissProt: Q14896 Human
- Unigene: 524906 Human
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別名
- C protein cardiac muscle isoform antibody
- C-protein antibody
- cardiac muscle isoform antibody
see all
画像
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Anti-MYBPC3 antibody [EPR3008(2)] (ab108522) at 1/5000 dilution (purified) + Human heart tissue lysate at 10 µg
Secondary
Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/20000 dilution
Predicted band size: 141 kDa
Observed band size: 141 kDaBlocking and dilution buffer: 5% NFDM /TBST.
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Anti-MYBPC3 antibody [EPR3008(2)] (ab108522) at 1/1000 dilution (unpurified) + Human heart tissue lysate at 10 µg
Predicted band size: 141 kDa
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab108522 は論文での使用が確認できていません。