製品の概要

  • 製品名Anti-MYBPC3 antibody
    MYBPC3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MYBPC3
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide derived from internal region of Human MYBPC3.

  • ポジティブ・コントロール
    • Human heart tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol
    Note: PBS (without Mg2+ and Ca2+)
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab110832 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab110832 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
  • 関連疾患Defects in MYBPC3 are the cause of cardiomyopathy familial hypertrophic type 4 (CMH4) [MIM:115197]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 配列類似性Belongs to the immunoglobulin superfamily. MyBP family.
    Contains 3 fibronectin type-III domains.
    Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
  • 翻訳後修飾Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C protein cardiac muscle isoform antibody
    • C-protein antibody
    • cardiac muscle isoform antibody
    • Cardiac MyBP C antibody
    • Cardiac MyBP-C antibody
    • cardiac-type antibody
    • MYBPC3 antibody
    • myosin binding protein C cardiac antibody
    • Myosin binding protein C cardiac type antibody
    • Myosin-binding protein C antibody
    • MYPC3_HUMAN antibody
    see all

Anti-MYBPC3 antibody 画像

  • ab110832 at 1/50 staining MYBPC3 in paraffin-embedded Human Heart tissue, left panel shows staining without peptide right panel shows staining with peptide.

Anti-MYBPC3 antibody (ab110832) 使用論文

ab110832 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"