製品の概要

  • 製品名Anti-MXI1 antibody
    MXI1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to MXI1
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 73-183 of human MXI1 (NP_001008541) with a 26 kDa tag.

  • ポジティブ・コントロール
    • MXI1 transfected 293T cell lysate. Recombinant tagged human MXI1 fragment (the immunogen).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab76881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 33 kDa.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
  • 組織特異性High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
  • 関連疾患Defects in MXI1 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • 配列類似性Contains 1 basic helix-loop-helix (bHLH) domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • bHLHc11 antibody
    • Class C basic helix-loop-helix protein 11 antibody
    • MAD 2 antibody
    • MAD2 antibody
    • MAX dimerization protein 2 antibody
    • MAX interacting protein 1 antibody
    • Max interactor 1 antibody
    • Max related transcription factor antibody
    • MAX-interacting protein 1 antibody
    • MGC43220 antibody
    • MXD 2 antibody
    • MXD2 antibody
    • MXI 1 antibody
    • MXI antibody
    • mxi1 antibody
    • MXI1 protein antibody
    • MXI1_HUMAN antibody
    • Protein MXI1 antibody
    see all

Anti-MXI1 antibody 画像

  • Anti-MXI1 antibody (ab76881) at 5 µg/ml + Recombinant tagged MXI1 fragment at 0.2 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

    Predicted band size : 33 kDa
    Observed band size : 38 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-MXI1 antibody (ab76881) at 5 µg/ml

    Lane 1 : MXI1 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 33 kDa
    Observed band size : 24 kDa (why is the actual band size different from the predicted?)

Anti-MXI1 antibody (ab76881) 使用論文

ab76881 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"