製品の概要

  • 製品名Anti-MXI1 antibody
    MXI1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MXI1
  • 特異性ab29740 recognises MAX interacting protein 1 (MXI1)
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide derived from residues 176 - 225 of human MXI1. Note: the amino acid sequence is proprietary).

  • ポジティブ・コントロール
    • Fetal Brain lysate Human Lung tissue

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab28740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
WB Use a concentration of 1 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 33 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
  • 組織特異性High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
  • 関連疾患Defects in MXI1 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • 配列類似性Contains 1 basic helix-loop-helix (bHLH) domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • bHLHc11 antibody
    • Class C basic helix-loop-helix protein 11 antibody
    • MAD 2 antibody
    • MAD2 antibody
    • MAX dimerization protein 2 antibody
    • MAX interacting protein 1 antibody
    • Max interactor 1 antibody
    • Max related transcription factor antibody
    • MAX-interacting protein 1 antibody
    • MGC43220 antibody
    • MXD 2 antibody
    • MXD2 antibody
    • MXI 1 antibody
    • MXI antibody
    • mxi1 antibody
    • MXI1 protein antibody
    • MXI1_HUMAN antibody
    • Protein MXI1 antibody
    see all

Anti-MXI1 antibody 画像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling MXI1 with ab28740 at 4-8µg/ml. Positively labelled cells are (indicated by arrows) are bronchiole epithelial cells. Magnification: X400.

  • Anti-MXI1 antibody (ab28740) at 1 µg/ml + Foetal brain lysate

    Secondary
    HRP conjugated anti-Rabbit IgG diluted 1/50,000 - 1/100,000

    Predicted band size : 33 kDa
    Observed band size : ~37 kDa (why is the actual band size different from the predicted?)

Anti-MXI1 antibody (ab28740) 使用論文

ab28740 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab28740.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"