Anti-MVP 抗体 [SPM280], prediluted (ab54301)

製品の概要

  • 製品名Anti-MVP antibody [SPM280], prediluted
    MVP 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [SPM280] to MVP, prediluted
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat
  • 免疫原

    Proteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells.

  • ポジティブ・コントロール
    • SKBR3 cells or breast carcinoma tissue.
  • 特記事項Ab with sodium azide is stable for 24 months when stored at 2-8°C.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab54301 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: Ready-to-use for 30 min at RT.
    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
    • 組織特異性Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
    • 配列類似性Contains 9 MVP (vault) repeats.
    • ドメインMVP 3 mediates interaction with PTEN.
      MVP 4 mediates interaction with PARP4.
    • 翻訳後修飾Phosphorylated on Tyr residues after EGF stimulation.
      Dephosphorylated by PTPN11.
    • 細胞内局在Cytoplasm. Nucleus > nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
    • Information by UniProt
    • 参照データベース
    • 別名
      • LRP antibody
      • Lung resistance related protein antibody
      • Lung resistance-related protein antibody
      • Major vault protein antibody
      • Major vault protein, rat, homolog of antibody
      • MVP antibody
      • MVP_HUMAN antibody
      • testicular secretory protein Li 30 antibody
      • VAULT 1 antibody
      • VAULT1 antibody
      see all

    Anti-MVP antibody [SPM280], prediluted 画像

    • ab54301 staining human MVP in human breast carcinoma tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue.

    Anti-MVP antibody [SPM280], prediluted (ab54301) 使用論文

    ab54301 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab54301.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"