製品の概要

  • 製品名Anti-MVP antibody
    MVP 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MVP
  • 特異性This antibody is specific for MVP.
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    A KLH conjugated synthetic peptide (10-30 aa in length) at the C-term of last 50 aa of human MVP.

  • ポジティブ・コントロール
    • A375 lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab38309 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 100 kDa (predicted molecular weight: 99 kDa).

ターゲット情報

  • 機能Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
  • 組織特異性Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
  • 配列類似性Contains 9 MVP (vault) repeats.
  • ドメインMVP 3 mediates interaction with PTEN.
    MVP 4 mediates interaction with PARP4.
  • 翻訳後修飾Phosphorylated on Tyr residues after EGF stimulation.
    Dephosphorylated by PTPN11.
  • 細胞内局在Cytoplasm. Nucleus > nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
  • Information by UniProt
  • 参照データベース
  • 別名
    • LRP antibody
    • Lung resistance related protein antibody
    • Lung resistance-related protein antibody
    • Major vault protein antibody
    • Major vault protein, rat, homolog of antibody
    • MVP antibody
    • MVP_HUMAN antibody
    • testicular secretory protein Li 30 antibody
    • VAULT 1 antibody
    • VAULT1 antibody
    see all

Anti-MVP antibody 画像

  • Anti-MVP antibody (ab38309) at 1/100 dilution + A375 lysate

    Predicted band size : 99 kDa
    Observed band size : 100 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 25 kDa,60 kDa,75 kDa. We are unsure as to the identity of these extra bands.

Anti-MVP antibody (ab38309) 使用論文

ab38309 has not yet been referenced specifically in any publications.

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