製品の概要

  • 製品名Anti-MVP antibody
    MVP 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MVP
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    QAPQAPGDNHVVPVLR

    conjugated to KLH, corresponding to C terminal amino acids 878-893 of Human MVP (NP_059447.2).

  • ポジティブ・コントロール
    • Human Testis tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab115928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
  • 組織特異性Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
  • 配列類似性Contains 9 MVP (vault) repeats.
  • ドメインMVP 3 mediates interaction with PTEN.
    MVP 4 mediates interaction with PARP4.
  • 翻訳後修飾Phosphorylated on Tyr residues after EGF stimulation.
    Dephosphorylated by PTPN11.
  • 細胞内局在Cytoplasm. Nucleus > nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
  • Information by UniProt
  • 参照データベース
  • 別名
    • LRP antibody
    • Lung resistance related protein antibody
    • Lung resistance-related protein antibody
    • Major vault protein antibody
    • Major vault protein, rat, homolog of antibody
    • MVP antibody
    • MVP_HUMAN antibody
    • testicular secretory protein Li 30 antibody
    • VAULT 1 antibody
    • VAULT1 antibody
    see all

Anti-MVP antibody 画像

  • ab115928, at 10 µg/ml, staining MVP in Formalin-fixed, Paraffin-embedded Human Testis tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-MVP antibody (ab115928) 使用論文

ab115928 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"