Anti-MVK 抗体 - Aminoterminal end (ab71458)

製品の概要

  • 製品名
    Anti-MVK antibody - Aminoterminal end
    MVK 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MVK - Aminoterminal end
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide (Human) conjugated to KLH

  • ポジティブ・コントロール
    • Mouse kidney cytoplasmic lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab71458 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 42 kDa.

ターゲット情報

  • 機能
    May be a regulatory site in cholesterol biosynthetic pathway.
  • パスウェイ
    Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
  • 関連疾患
    Defects in MVK are the cause of mevalonic aciduria (MEVA) [MIM:610377]. It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia.
    Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) [MIM:260920]. HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal.
  • 配列類似性
    Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
  • 細胞内局在
    Cytoplasm. Peroxisome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ96772 antibody
    • KIME_HUMAN antibody
    • LH receptor mRNA binding protein antibody
    • LRBP antibody
    • Mevalonate kinase 1 antibody
    • Mevalonate kinase antibody
    • Mevalonic aciduria antibody
    • MK antibody
    • mvk antibody
    • MVLK antibody
    • POROK3 antibody
    see all

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プロトコール

参考文献

ab71458 has not yet been referenced specifically in any publications.

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