製品の概要

  • 製品名Anti-MVK antibody
    MVK 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MVK
  • 特異性Detects endogenous levels of total MVK protein.
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide derived from an internal region of human MVK

  • ポジティブ・コントロール
    • Human brain tisue Cos7 cell extract COLO205 cell extract

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab72588 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
ELISA 1/10000.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能May be a regulatory site in cholesterol biosynthetic pathway.
  • パスウェイIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
  • 関連疾患Defects in MVK are the cause of mevalonic aciduria (MEVA) [MIM:610377]. It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia.
    Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) [MIM:260920]. HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal.
  • 配列類似性Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
  • 細胞内局在Cytoplasm. Peroxisome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ96772 antibody
    • KIME_HUMAN antibody
    • LH receptor mRNA binding protein antibody
    • LRBP antibody
    • Mevalonate kinase 1 antibody
    • Mevalonate kinase antibody
    • Mevalonic aciduria antibody
    • MK antibody
    • mvk antibody
    • MVLK antibody
    • POROK3 antibody
    see all

Anti-MVK antibody 画像

  • Immunohistochemical analysis of paraffin-embedded human brain tissue using ab72588 at 1/50 dilution. Right panel was also treated with immunising peptide.
  • All lanes : Anti-MVK antibody (ab72588) at 1/500 dilution

    Lane 1 : Cos7 cell extract
    Lane 2 : COLO205 cell extract
    Lane 3 : COLO205 cell extract with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 42 kDa
    Observed band size : 42 kDa
    Additional bands at : 80 kDa. We are unsure as to the identity of these extra bands.

Anti-MVK antibody (ab72588) 使用論文

ab72588 has not yet been referenced specifically in any publications.

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